Peripheral Nerve Disorders 2

Author: Arthur K. Asbury
Publisher: Butterworth-Heinemann Medical
ISBN:
Size: 26.81 MB
Format: PDF, Mobi
View: 5936
Download Read Online

Peripheral Nerve Disorders 2 from the Author: Arthur K. Asbury. The flow of new information in the eleven years since the publication of the first volume (published in the BIMR series), has long necessitated a new look at peripheral nerve disorders. Thus this new volume emphasises the advances of the past decade and includes information on newly recognized neuropathies, hereditary neuropathies, peripheral nerve dysfunction and therapeutic advances. It has over 20 contributors from the UK, USA and continental Europe.

Peripheral Nerve Disorders

Author: Simon K.W. Lloyd
Publisher: Elsevier Inc. Chapters
ISBN: 0128078855
Size: 57.46 MB
Format: PDF
View: 5420
Download Read Online

Peripheral Nerve Disorders from the Author: Simon K.W. Lloyd. Neurofibromatosis type 2 (NF2) is an autosomal dominant inherited tumor predisposition syndrome caused by mutations in the NF2 gene on chromosome 22. Affected individuals develop schwannomas typically involving both vestibular nerves leading to hearing loss and eventual deafness. Rehabilitation with brainstem implants and in some cases cochlear implants is improving this outcome. Schwannomas also occur on other cranial nerves, on spinal nerve roots and peripheral nerves, and intracutaneously as plaques. Cranial and spinal meningiomas and spinal ependymomas are other common tumors. Fifty to sixty percent of patients represent de novo mutations and as many as 33% of these are mosaic for the underlying disease causing mutation. Truncating mutations (nonsense, frameshift insertions/deletions) are the most frequent germline events and cause the most severe disease, whilst single and multiple exon deletions are common and are usually associated with milder NF2. Neurological deficits are a major feature of the condition and neurologists have a pivotal role in assigning symptoms to lesions and in managing neuropathies. NF2 represents a difficult management problem with most patients facing substantial morbidity and reduced life expectancy. Surgery remains the focus of current management although watchful waiting and occasionally radiation treatment have a role. We are seeing the advent of tailored drug therapies aimed at the genetic level and these are likely to provide huge improvements for this devastating, life-limiting condition.

Peripheral Nerve Disorders

Author: GĂ©rard Said
Publisher: Elsevier
ISBN: 0444633553
Size: 78.20 MB
Format: PDF, Docs
View: 5444
Download Read Online

Peripheral Nerve Disorders from the Author: GĂ©rard Said. Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities. Covers both hereditary and cryptogenic neurologic disorders Includes advances in the basic science of PNS from molecular genetics, biochemistry, immunology, morphology and physiology Detailed coverage of neuropathy in connective tissue disorders, infectious disorders, metabolic disorders and malignancy

Peripheral Nerve Disorders

Author: Jean-Michel Vallat
Publisher: John Wiley & Sons
ISBN: 1118618416
Size: 42.38 MB
Format: PDF, ePub
View: 1237
Download Read Online

Peripheral Nerve Disorders from the Author: Jean-Michel Vallat. Peripheral Nerve Disorders: Pathology and Genetics is a definitive, clinically-oriented guide to the pathology of peripheral nerve disorders. These commonly seen neurological challenges have many causes and accurate diagnosis is often necessary via pathological analysis. New techniques exploiting molecular biological knowledge have opened up new vistas to understanding the pathogenesis of these disorders, and hence their effective management. This new title takes a disease-oriented approach to understanding the pathology of these conditions. It combines classical and contemporary techniques to enable practitioners in neurology and neuropathology to better understanding of the disease processes underlying patients’ presentations and to formulate appropriate management plans. Peripheral Nerve Disorders: Pathology and Genetics is a valuable resource for neurologists, neuropathologists, pathologists, neurobiologists and geneticists.

Diagnosis And Management Of Peripheral Nerve Disorders

Author: Jerry R. Mendell
Publisher: Oxford University Press
ISBN: 0195133013
Size: 36.89 MB
Format: PDF, ePub, Docs
View: 7037
Download Read Online

Diagnosis And Management Of Peripheral Nerve Disorders from the Author: Jerry R. Mendell. Peripheral neuropathies represent a challenging subject for most physicians. This is an up-to-date, comprehensive, and readable book on peripheral neuropathies that includes concise information on the clinical, electrophysiological, pathological, pathogenic, and treatment aspects of the most important disorders. New molecular and serologic diagnostic tests are discussed. Sections are devoted to nerve and skin biopsy techniques and findings, quantitative sensory and autonomic reflex tests. Case examples are used liberally throughout the text. The editors: Mendell, Kissel, and Cornblath are experienced clinicians that bring complementary knowledge to each of the subjects. Additional authors have been handpicked for specific topics which add to the value of the edition.

Peripheral Nerve Disorders

Author: GĂ©rard Said
Publisher: Elsevier
ISBN: 0444633553
Size: 49.99 MB
Format: PDF, Mobi
View: 2560
Download Read Online

Peripheral Nerve Disorders from the Author: GĂ©rard Said. Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities. Covers both hereditary and cryptogenic neurologic disorders Includes advances in the basic science of PNS from molecular genetics, biochemistry, immunology, morphology and physiology Detailed coverage of neuropathy in connective tissue disorders, infectious disorders, metabolic disorders and malignancy

Peripheral Nerve Disorders

Author: Israel Steiner
Publisher: Elsevier Inc. Chapters
ISBN: 0128078626
Size: 56.48 MB
Format: PDF
View: 4179
Download Read Online

Peripheral Nerve Disorders from the Author: Israel Steiner. Among the human herpes viruses, three are neurotropic and capable of producing severe neurological abnormalities: herpes simplex virus type 1 and 2 (HSV-1 and HSV-2) and varicella-zoster virus (VZV). Both the acute, primary infection and the reactivation from the site of latent infection, the dorsal sensory ganglia, are associated with severe human morbidity and mortality. The peripheral nervous system is one of the major loci affected by these viruses. The present review details the virology and molecular biology underlying the human infection. This is followed by detailed description of the symtomatology, clinical presentation, diagnosis, course, therapy, and prognosis of disorders of the peripheral nervous system caused by these viruses.

Peripheral Nerve Disorders

Author: Andrea M. Vincent
Publisher: Elsevier Inc. Chapters
ISBN: 0128078650
Size: 44.22 MB
Format: PDF, Mobi
View: 6897
Download Read Online

Peripheral Nerve Disorders from the Author: Andrea M. Vincent. More than half of all patients with diabetes develop neuropathic disorders affecting the distal sensory and/or motor nerves, or autonomic or cranial nerve functions. Glycemic control can decrease the incidence of neuropathy but is not adequate alone to prevent or treat the disease. This chapter introduces diabetic neuropathy with a morphological description of the disease then describes our current understanding of metabolic and molecular mechanisms that contribute to neurovascular dysfunctions. Key mechanisms include glucose and lipid imbalances and insulin resistance that are interconnected via oxidative stress, inflammation, and altered gene expression. These complex interactions should be considered for the development of new treatment strategies against the onset or progression of neuropathy. Advances in understanding the combined metabolic stressors and the novel study of epigenetics suggest new therapeutic targets to combat this morbid and intractable disease affecting millions of patients with type 1 or type 2 diabetes.

Peripheral Nerve Disorders

Author: Kurien Koshy
Publisher: Elsevier Inc. Chapters
ISBN: 0128078758
Size: 31.72 MB
Format: PDF, Kindle
View: 4036
Download Read Online

Peripheral Nerve Disorders from the Author: Kurien Koshy. Patients admitted to intensive care units (ICUs) suffer from a wide range of neurological disorders. Some develop within the ICU rendering weakness and difficulty in weaning patients from ventilator support. ICUAW, or ICU acquired weakness, is a broad term that includes several more specific neuromuscular problems. After exclusion of other causes of weakness, ICUAW includes critical illness polyneuropathy (CIP), first described by Charles Bolton, critical illness myopathy (CIM), and disorders of neuromuscular junction transmission. This chapter reviews the clinical, electrophysiological, and pathological features of these conditions and provides clinicians with approaches toward diagnosing and investigating ICUAW.

Diagnosis And Management Of Peripheral Nerve Disorders

Author: Jerry R. Mendell
Publisher: Oxford University Press
ISBN: 9780198030485
Size: 79.72 MB
Format: PDF, Kindle
View: 2596
Download Read Online

Diagnosis And Management Of Peripheral Nerve Disorders from the Author: Jerry R. Mendell. Peripheral neuropathies represent a challenging subject for most physicians. This is an up-to-date, comprehensive, and readable book on peripheral neuropathies that includes concise information on the clinical, electrophysiological, pathological, pathogenic, and treatment aspects of the most important disorders. New molecular and serologic diagnostic tests are discussed. Sections are devoted to nerve and skin biopsy techniques and findings, quantitative sensory and autonomic reflex tests. Case examples are used liberally throughout the text. The editors: Mendell, Kissel, and Cornblath are experienced clinicians that bring complementary knowledge to each of the subjects. Additional authors have been handpicked for specific topics which add to the value of the edition.