Cryptosporidiosis And Microsporidiosis

Author: Franz Petry
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805570503
Size: 45.16 MB
Format: PDF, ePub
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Cryptosporidiosis And Microsporidiosis from the Author: Franz Petry. '... This volume provides most complete and balanced coverage of essential aspects of the pathogens as well as the diagnosis and clinical correlations of the disease they cause. It is set to become a valuable refrence for parasitologists, protozoologists, molecular biologists, clinical mecrobiologists, epidemiologists and specialists in infectious diseases.'

The Microsporidia And Microsporidiosis

Author: Murray Wittner
Publisher: Amer Society for Microbiology
Size: 78.26 MB
Format: PDF, Kindle
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The Microsporidia And Microsporidiosis from the Author: Murray Wittner. Addresses all aspects of microsporidia and microsporidiosis, provides biologists, physicians, and research scientists with a complete, modern view of this increasingly important group of parasites.


Author: Louis M. Weiss
Publisher: John Wiley & Sons
ISBN: 1118395239
Size: 59.24 MB
Format: PDF, Mobi
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Microsporidia from the Author: Louis M. Weiss. Microsporidia: Pathogens of Opportunity provides a systematic overview of the biology of microsporidia. Written by leading experts in the field, the book combines background and basic information on microsporidia with descriptive methods and resources for working with the pathogen. Newly revised and updated for its second edition, Microsporidia will continue to be the standard text reference for these pathogenic protists, and is an indispensable research resource for biologists, physicians and parasitologists. This new edition of this publication provides systematic reviews of the biology of this pathogen by leading experts in the field, and will be combined with descriptions of the methods and resources for working with this pathogen. • Provides a comprehensive summary of literature on microsporidia and microsporidiosis • The long-awaited update to the standard microsporidia reference text The Microsporidia and Microsporidiosis • Written by an international team of authors representing each of the main research groups working on microsporidia • Chapters provide comprehensive overviews of general methodology as well as special techniques related to these organisms

Examination Of Microsporidia Spore Adherence And Host Cell Infection In Vitro

Size: 34.41 MB
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Examination Of Microsporidia Spore Adherence And Host Cell Infection In Vitro from the Author: . Microsporidia are obligate intracellular pathogens that cause severe disease in immunocompromised humans. While albendazole is the treatment of choice, no therapy exists that effectively treats all forms or causes of human microsporidiosis. Recent studies show that the microsporidian Encephalitozoon intestinalis binds glycosaminoglycans (GAGs) associated with the host cell surface, and that the divalent cations manganese (Mn2+) and magnesium (Mg2+) augment spore adherence to host cells by activating a constituent on the spore surface. These studies also illustrate a direct relationship between spore adherence and host cell infection; inhibition of spore adherence leads to reduced host cell infection while augmentation of spore adherence increases host cell infection. In light of recent studies, microsporidia spore adherence has become a promising target for the development of novel therapeutics to treat or even prevent human microsporidiosis. The goal of this study was to further characterize the molecular mechanisms governing spore adherence by identifying specific constituents on microsporidia spores that participate in spore adherence with host cells. A 40 kDa Encephalitozoon cuniculi host cell binding protein was discovered and identified as ECU01_0820, hereafter known as Encephalitozoon cuniculi microsporidia spore adherence protein (EcMsAP). The gene encoding EcMsAP has multiple heparin-binding motifs and an integrin-binding domain, which are characteristic of proteins that interact with constituents on the cell surface. Immuno-transmission electron microscopy reveals that native EcMsAP is located on the plasma membrane, endospore, exospore, and the anchoring disk of microsporidia spores. Recombinant EcMsAP and antibodies to recombinant EcMsAP both inhibit spore adherence and host cell infection. However, the deletion of heparin-binding motif #1 from the EcMsAP gene results in the loss of ability to inhibit spore adherence and infection. Host cell-binding assa.


Author: Jeana M. Stubbert
Size: 68.77 MB
Format: PDF, Mobi
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Microsporidia from the Author: Jeana M. Stubbert.

Biology Of The Microsporidia

Author: Lee A. Bulla
Publisher: Springer Science & Business Media
ISBN: 1468431145
Size: 35.38 MB
Format: PDF
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Biology Of The Microsporidia from the Author: Lee A. Bulla. This is the introductory volume of a new series to be issued under our general editorship. With the development of an unpre cedented increase in interest in comparative pathobiology, we are of the opinion and intent that Comparative PathobioZogy should become the focal point for the publication of definitive reviews and the proceedings of significant symposia in this area of modern biomedical science. Although the term is now in common use, the question is still sometimes raised as to what "pathobiology" includes. This broad area of modern biology includes but extends beyond traditional pathology. It also encompasses studies directed at understanding the biology, chemistry, and physics of infectious agents, in cluding how they contact and invade the effected organism; the reactions of hosts to such agents, as well as to abiotic invaders; the ecologic parameters which facilitate infection; and the development of tools essential for the understanding of hast pathogen interactions. In other words, pathobiology is inter disciplinary and incorporates all of those aspects of biology, chemistry, and physics which directly or indirectly permit greater understanding of the nature of infectious and noninfectious diseases and the possible implications of such in biomedicine, agriculture, and environmental science. By "comparative" is meant an analytical and critical evaluation of comparable processes as they apply to all categories of animals, invertebrates as well as poikilothermic and homeothermic verte brates.