Mechanotransduction

Author:
Publisher: Academic Press
ISBN: 0123983274
Size: 60.67 MB
Format: PDF
View: 3729
Download Read Online

Mechanotransduction from the Author: . Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. Provides a unique combination of perspectives from biologists and engineers Engaging to people of many training backgrounds

Mechanosensitivity And Mechanotransduction

Author: Irina Kiseleva
Publisher: Springer Science & Business Media
ISBN: 9789048198818
Size: 59.61 MB
Format: PDF
View: 2537
Download Read Online

Mechanosensitivity And Mechanotransduction from the Author: Irina Kiseleva. This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Cardiac Mechanotransduction

Author: Matti Weckström
Publisher: Springer Science & Business Media
ISBN: 9780387488684
Size: 60.71 MB
Format: PDF, ePub, Mobi
View: 5986
Download Read Online

Cardiac Mechanotransduction from the Author: Matti Weckström. This book presents a multidisciplinary approach to cardiac mechanotransduction. The chapters depict the many faces of the topic, from membrane and ion channel level to mechanics, biochemical signaling and regulation via hormone systems. Cardiac Mechanotransduction is of interest to basic life sciences, like physiology, biochemistry and pharmacology, but also to clinicians working with heart-related problems, such as cardiologists and internists.

Mechanotransduction

Author: Mechanotransduction and Translational Medicine Workshop
Publisher: ICON Group International
ISBN:
Size: 16.77 MB
Format: PDF, ePub, Mobi
View: 3553
Download Read Online

Mechanotransduction from the Author: Mechanotransduction and Translational Medicine Workshop.

Cellular Mechanotransduction

Author: Mohammad R. K. Mofrad
Publisher: Cambridge University Press
ISBN: 9781107682467
Size: 64.90 MB
Format: PDF, Kindle
View: 5317
Download Read Online

Cellular Mechanotransduction from the Author: Mohammad R. K. Mofrad. "Mechanotransduction" is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of biological responses it produces. This book looks at mechanotransduction in a more restricted sense, focusing on the process of stress sensing and transducing a mechanical force into a cascade of biochemical signals. This stress has become increasingly recognized as one of the primary and essential factors controlling biological functions, ultimately affecting the function of the cells, tissues, and organs. A primary goal of this broad book is also to help define the new field of mechanomics, which attempts to describe the complete mechanical state of a biological system.

Mechanotransduction In Mitotic Spindle Positioning

Author: Jenny Fink
Publisher:
ISBN:
Size: 63.16 MB
Format: PDF, ePub, Mobi
View: 3759
Download Read Online

Mechanotransduction In Mitotic Spindle Positioning from the Author: Jenny Fink. In mitosis, positioning of the microtubule spindle represents a key process that is conserved from yeast to animal cells. It is essential for cell fate, development and tissue organization and perturbations of this process can have as dramatic effects as uncontrolled cell dissemination and death of the whole organism. In animal cells, external stimuli are thought to polarize the actin cortex, and this polarization is subsequently transduced to the microtubule spindle leading to its positioning. During my thesis, I studied the influence of extracellular pulling forces on mitotic spindle orientation in cultured cells. We demonstrated that these extracellular forces that were transmitted to the mitotic cell body via retraction fibres could direct spindle positioning. We thus identified a novel function for mechanotransduction, i.e. the conversion of mechanical forces into biochemical signals that finally induce a cellular response, in the context of mitotic spindle positioning. These findings additionally demonstrate that biochemical cues -predominantly investigated by previous studies - are not the only important signals regulating spindle positioning. We could furthermore show that the actin cortex is mechanically polarized during mitosis: one cortex quadrant was often up to twice stiffer than the remaining three quadrants. The mitotic spindle appeared to be aligned with this stiffness gradient, one pole facing the stiffest quadrant. Simulations of spindle dynamics, performed in the group of François Nedelec, could predict this observed behaviour when using our measured parameters for cortical rigidity and microtubule dynamics.

Mechanics Of Biological Systems And Materials Volume 7

Author: Francois Barthelat
Publisher: Springer
ISBN: 3319069748
Size: 21.25 MB
Format: PDF
View: 6979
Download Read Online

Mechanics Of Biological Systems And Materials Volume 7 from the Author: Francois Barthelat. Mechanics of Biological Systems and Materials, Volume 7: Proceedings of the 2014 Annual Conference on Experimental and Applied Mechanics, the seventh volume of eight from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on a wide range of areas, including: Soft Tissues Mechanics Natural Materials & Bio-Inspiration Tissue Engineering Cells Mechanics