Mechanosensitivity And Mechanotransduction

Author: Irina Kiseleva
Publisher: Springer Science & Business Media
ISBN: 9789048198818
Size: 73.12 MB
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Mechanosensitivity And Mechanotransduction from the Author: Irina Kiseleva. This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.


Publisher: Academic Press
ISBN: 0123983274
Size: 28.74 MB
Format: PDF, ePub, Docs
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Mechanotransduction from the Author: . Progress in Molecular Biology and Translational Science provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Volume 126 features in-depth reviews that focus on the tools required to investigate mechanotransduction. Additional chapters focus on how we can use these tools to answer fundamental questions about the interaction of physical forces with cell biology, morphogenesis, and function of mature structures. Chapters in the volume are authored by a unique combination of cell biologists and engineers, providing a range of perspectives on mechanotransduction. Provides a unique combination of perspectives from biologists and engineers Engaging to people of many training backgrounds

Cardiac Mechanotransduction

Author: Matti Weckström
Publisher: Springer Science & Business Media
ISBN: 9780387488684
Size: 36.98 MB
Format: PDF, ePub
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Cardiac Mechanotransduction from the Author: Matti Weckström. This book presents a multidisciplinary approach to cardiac mechanotransduction. The chapters depict the many faces of the topic, from membrane and ion channel level to mechanics, biochemical signaling and regulation via hormone systems. Cardiac Mechanotransduction is of interest to basic life sciences, like physiology, biochemistry and pharmacology, but also to clinicians working with heart-related problems, such as cardiologists and internists.


Author: Mechanotransduction and Translational Medicine Workshop
Publisher: ICON Group International
Size: 12.49 MB
Format: PDF, ePub, Docs
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Mechanotransduction from the Author: Mechanotransduction and Translational Medicine Workshop.

Cellular Mechanotransduction

Author: Mohammad R. K. Mofrad
Publisher: Cambridge University Press
ISBN: 1316139476
Size: 73.64 MB
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Cellular Mechanotransduction from the Author: Mohammad R. K. Mofrad. 'Mechanotransduction' is the term for the ability, first described by 19th-century anatomist Julius Wolff, of living tissues to sense mechanical stress and respond by tissue remodeling. More recently, the scope of mechanotransduction has been expanded to include the sensation of stress, its translation into a biochemical signal, and the sequence of biological responses it produces. This book looks at mechanotransduction in a more restricted sense, focusing on the process of stress sensing and transducing a mechanical force into a cascade of biochemical signals. This stress has become increasingly recognized as one of the primary and essential factors controlling biological functions, ultimately affecting the function of the cells, tissues, and organs. A primary goal of this broad book is also to help define the new field of mechanomics, which attempts to describe the complete mechanical state of a biological system.

The Mechanotransduction Of Primary Cilia In Tumor Progression Of Lung Adenocarcinoma

Author: Sagar Sunil Patel
Size: 57.52 MB
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The Mechanotransduction Of Primary Cilia In Tumor Progression Of Lung Adenocarcinoma from the Author: Sagar Sunil Patel. The objective of this study was to investigate primary cilia and their mechanotransduction role in lung adenocarcinoma tumor progression. The main focus investigated the effect of primary cilia on cell cycle progression, survival, adhesion and migration analysis of these cells and the role of sonic hedgehog signaling pathway in mechanotransduction. Human Non-Small Cell Lung Cancer (NSCLC) adenocarcinoma biopsies contain more primary cilia than non-tumor lung sections. To observe the effects of primary cilia presence in lung cancer cells in-vitro, formation of primary cilia is inhibited using small interfering RNA. A549 cells with intact primary cilia observe less cell cycle progression than cells deficient in primary cilia under static and cyclic stretch conditions. Primary cilia cause higher cell survival and adhesion. Increase in cell adhesion also increases the migration and wound closure rates in control samples compared to samples treated with inhibition of IFT88, thereby increasing the metastasis of these cells. Several downstream regulatory genes in sonic hedgehog signaling pathway observe significantly decreased gene expressions in primary cilia deficient cells, thus indicating inefficient mechanotransduction. Therefore, cancer cells need primary cilia to survive, adhere and migrate and continue tumor progression.

Mechanics Of Biological Systems And Materials Volume 7

Author: Francois Barthelat
Publisher: Springer
ISBN: 3319069748
Size: 64.90 MB
Format: PDF, Mobi
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Mechanics Of Biological Systems And Materials Volume 7 from the Author: Francois Barthelat. Mechanics of Biological Systems and Materials, Volume 7: Proceedings of the 2014 Annual Conference on Experimental and Applied Mechanics, the seventh volume of eight from the Conference, brings together contributions to this important area of research and engineering. The collection presents early findings and case studies on a wide range of areas, including: Soft Tissues Mechanics Natural Materials & Bio-Inspiration Tissue Engineering Cells Mechanics

Handbook Of Imaging In Biological Mechanics

Author: Corey P. Neu
Publisher: CRC Press
ISBN: 1466588144
Size: 36.39 MB
Format: PDF, Kindle
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Handbook Of Imaging In Biological Mechanics from the Author: Corey P. Neu. Emerging imaging techniques have opened new fronts to investigate tissues, cells, and proteins. Transformative technologies such as microCT scans, super-resolution microscopy, fluorescence-based tools, and other methods now allow us to study the mechanics of cancer, dissect the origins of cellular force regulation, and examine biological specimens at the nanoscale. The Handbook of Imaging in Biological Mechanics presents the spectrum of imaging techniques used for noninvasive visualization of the morphology and mechanics of the large and small—from organs to individual macromolecules. The handbook presents optimal imaging technologies to study deformation, stress, and constitutive behavior of tissues, cells, and proteins. It also describes a suite of technologies available for probing the mechanics of surfaces, membranes, and single molecules. With chapters authored by highly recognized experts in their area, the handbook covers the entire spectrum of biomechanical and mechanobiologic imaging technologies available today.