Mechanosensitivity And Mechanotransduction

Author: Irina Kiseleva
Publisher: Springer Science & Business Media
ISBN: 9789048198818
Size: 46.24 MB
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Mechanosensitivity And Mechanotransduction from the Author: Irina Kiseleva. This book presents the latest findings in the field of research of mechanosensitivity and mechanotransduction in different cells and tissues. Mechanosensitivity and mechanotransduction of the heart and vascular cells, in the lung, in bone and joint tissues, in sensor systems and in blood cells are described in detail. This Volume focuses on molecular mechanisms of mechanosensitivity and mechanotransduction via cytoskeleton. Integrin-mediated mechanotransduction, the role of actin cytoskeleton and the role of other cytoskeletal elements are discussed. It contains a detailed description of several stretch-induced signaling cascades with multiple levels of crosstalk between different pathways. It contains a description of the role of nitric oxide in regulation of cardiac activity and in regulation of mechanically gated channels in the heart. In the heart mechanical signals are propagated into the intracellular space primarily via integrin-linked complexes, and are subsequently transmitted from cell to cell via paracrine signaling. Biochemical signals derived from mechanical stimuli activate both acute phosphorylation of signaling cascades, such as in the PI3K, FAK, and ILK pathways, and long-term morphological modii cations via intracellular cytoskeletal reorganization and extracellular matrix remodelling. Cellular and molecular effects of mechanical stretch on vascular cells are also discussed. This Volume highlights the role of mechanotransduction in the lung, in bone and joint tissues. For the first time mechanosensitivity and mechanotransduction in blood cells are discussed. It contains new insights into mechanosensitive K+ channels functioning in mouse B lymphocytes. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Currently, investigations of the molecular mechanisms of mechanosensitivity and mechanotransduction are focused on several issues. The majority of studies investigate intracellular signaling pathways. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different organs and tissues and allows to predict changes, which arise due to alterations of their environment. Possibly such knowledge will allow the development of new methods of artificial intervention and therapies. This book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

Mechanosensitive Ion Channels

Author:
Publisher: Academic Press
ISBN: 0080494404
Size: 75.73 MB
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Mechanosensitive Ion Channels from the Author: . Current Topics in Membranes provides a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include ENaC Proteins in Vascular Smooth Muscle Mechanotransduction; Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids; MechanoTRPs and TRPA1; TRPC; The Cytoskeletal Connection to Ion Channels as a Potential Mechanosensory Mechanism. Lessons From Polycystin-2 (TRPP2); Lipid Stress at Play: Mechanosensitivity of Voltage-Gated Channels; Hair Cell Mechanotransduction: The Dynamic Interplay between Structure and Function; Pharmacology of Hair Cell MS Channels; Hair Cell Mechanotransduction; Models of Hair Cell Mechanotrasduction; Touch; Mechanosensitive Ion Channels in Dystrophic Muscle; Mechanotransduction in Endothelial Cells; MS Channels in Tumor Cell Migration; Mechanosensitive Channels in Regulating Smooth Muscle Contraction in the GI; Mechanosensitive Ion Channels in Blood-Pressure-Sensing Baroreceptor Neurons.

Mechanosensitivity Of The Heart

Author: Andre Kamkin
Publisher: Springer Science & Business Media
ISBN: 9048128501
Size: 68.40 MB
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Mechanosensitivity Of The Heart from the Author: Andre Kamkin. This timely review of heart mechanosensitivity examines tissues at the molecular, biological, bio-physical, physiological and pharmaceutical levels. New insight on the electromechanical properties of cardiac tissue is supported with experimental results.

Mechanical Stretch And Cytokines

Author: Andre Kamkin
Publisher: Springer Science & Business Media
ISBN: 9789400720046
Size: 77.49 MB
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Mechanical Stretch And Cytokines from the Author: Andre Kamkin. This book presents the latest findings in the field of investigation of molecular mechanisms of mechanical stretch and the role of cytokines in response of different tissues to it. On the one hand this Volume demonstrates how mechanical stretch enhances cytokines production. It describes how cytokines influence tissues and cells on a background of a mechanical stretching. It provides a description of how cells in different tissues are activated by stretch and cytokines via various signaling pathways, and how they change their gene expression. The book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. Knowledge of biomechanics, and mechanisms which underlie it on molecular, cellular and tissue, is necessary for understanding of the normal functioning of living organisms and allows to predict changes, which arise due to alterations of their environment.

Mechanosensitive Ion Channels

Author: Andre Kamkin
Publisher: Springer Science & Business Media
ISBN: 1402064268
Size: 20.68 MB
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Mechanosensitive Ion Channels from the Author: Andre Kamkin. This book explores the latest data dealing with mechanosensitive channels research results. It was compiled by a group of internationally recognized scientists leading in the field of mechanosensitive ion channels or mechanically gated channels and signaling cascades research. Key problems of cell mechanobiology are also discussed. As a whole, the volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways.

Mechanically Gated Channels And Their Regulation

Author: Andre Kamkin
Publisher: Springer Science & Business Media
ISBN: 9400750730
Size: 61.92 MB
Format: PDF
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Mechanically Gated Channels And Their Regulation from the Author: Andre Kamkin. The volume dwells on the major issues of mechanical stress influencing the ion channels and intracellular signaling pathways. This book is a unique collection of reviews outlining current knowledge and future developments in this rapidly growing field. In our opinion the book presents not only the latest achievements in the field but also brings the problem closer to the experts in related medical and biological sciences as well as practicing doctors. Knowledge of the mechanisms which underlie these processes is necessary for understanding of the normal functioning of different living organs and tissues and allows to predict changes, which arise due to alterations of their environment, and possibly will allow to develop new methods of artificial intervention. We also hope that presenting the problem will attract more attention to it both from researchers and practitioners and will assist to efficiently introduce it into the practical medicine.

Comprehensive Biomaterials

Author: Paul Ducheyne
Publisher: Newnes
ISBN: 0080552943
Size: 65.79 MB
Format: PDF, ePub, Docs
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Comprehensive Biomaterials from the Author: Paul Ducheyne. Comprehensive Biomaterials brings together the myriad facets of biomaterials into one, major series of six edited volumes that would cover the field of biomaterials in a major, extensive fashion: Volume 1: Metallic, Ceramic and Polymeric Biomaterials Volume 2: Biologically Inspired and Biomolecular Materials Volume 3: Methods of Analysis Volume 4: Biocompatibility, Surface Engineering, and Delivery Of Drugs, Genes and Other Molecules Volume 5: Tissue and Organ Engineering Volume 6: Biomaterials and Clinical Use Experts from around the world in hundreds of related biomaterials areas have contributed to this publication, resulting in a continuum of rich information appropriate for many audiences. The work addresses the current status of nearly all biomaterials in the field, their strengths and weaknesses, their future prospects, appropriate analytical methods and testing, device applications and performance, emerging candidate materials as competitors and disruptive technologies, and strategic insights for those entering and operational in diverse biomaterials applications, research and development, regulatory management, and commercial aspects. From the outset, the goal was to review materials in the context of medical devices and tissue properties, biocompatibility and surface analysis, tissue engineering and controlled release. It was also the intent both, to focus on material properties from the perspectives of therapeutic and diagnostic use, and to address questions relevant to state-of-the-art research endeavors. Reviews the current status of nearly all biomaterials in the field by analyzing their strengths and weaknesses, performance as well as future prospects Presents appropriate analytical methods and testing procedures in addition to potential device applications Provides strategic insights for those working on diverse application areas such as R&D, regulatory management, and commercial development

Layer By Layer Films For Biomedical Applications

Author: Catherine Picart
Publisher: John Wiley & Sons
ISBN: 3527675884
Size: 54.54 MB
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Layer By Layer Films For Biomedical Applications from the Author: Catherine Picart. The layer-by-layer (LbL) deposition technique is a versatile approach for preparing nanoscale multimaterial films: the fabrication of multicomposite films by the LbL procedure allows the combination of literally hundreds of different materials with nanometer thickness in a single device to obtain novel or superior performance. In the last 15 years the LbL technique has seen considerable developments and has now reached a point where it is beginning to find applications in bioengineering and biomedical engineering. The book gives a thorough overview of applications of the LbL technique in the context of bioengineering and biomedical engineering where the last years have witnessed tremendous progress. The first part familiarizes the reader with the specifics of cell-film interactions that need to be taken into account for successful application of the LbL method in biological environments. The second part focuses on LbL-derived small drug delivery systems and antibacterial agents, and the third part covers nano- and microcapsules as drug carriers and biosensors. The fourth and last part focuses on larger-scale biomedical applications of the LbL method such as engineered tissues and implant coatings.

Mechanosensitivity Of The Nervous System

Author: Andre Kamkin
Publisher: Springer Science & Business Media
ISBN: 1402087160
Size: 25.73 MB
Format: PDF
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Mechanosensitivity Of The Nervous System from the Author: Andre Kamkin. This book presents the latest findings in mechanosensitivity of the nervous system. The nervous system stands out from a number of tissues because besides reacting to the mechanical stress it is transmitting its own response to other organs and tissues, which are located downstream of its signaling pathway. For this reason any type of mechanical stimulation of the nervous system, which is capable of triggering a physiological response, has high scientific and practical significance, since it allows its use beyond a particular experimental model anywhere where it is contributing to a particular pathological condition. This book is a unique collection of reviews outlining the current knowledge and the future developments in this rapidly growing field. Currently, investigations of the effects of mechanical stress on the nervous system are focused on several issues. The majority of studies investigate the effects of mechanical stimulation on mechanosensitive channels, as its primary target and interactive agent, and aim on description of downstream intracellular signaling pathways together with addressing general issues of biomechanics of the nervous system. Knowledge of biomechanics, and mechanisms, which underlie it on organism, organ, tissue and cellular level, is necessary for understanding of the normal functioning of living organisms and allows to predict changes which arise due to alterations of their environment, and possibly will allow to develop new methods of artificial intervention. The book brings up the problem closer to the experts in related medical and biological sciences as well as practicing doctors besides just presenting the latest achievements in the field.

The Handbook Of Touch

Author: Dr. Matthew J. Hertenstein, PhD
Publisher: Springer Publishing Company
ISBN: 0826121926
Size: 38.11 MB
Format: PDF, ePub, Mobi
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The Handbook Of Touch from the Author: Dr. Matthew J. Hertenstein, PhD. "This book is excellent in its coverage of neurobiological underpinnings through perception, measurement, and communication...a great resource for researchers and clinicians." Score: 94, 4 stars. --Doody's Medical Reviews "This is an expertly constructed volume, due mainly to an expert composition of authors forthe individual chapters. Every chapter is like opening a door to a different laboratory, eachexamining a unique corner of the tactile research universe."--PsycCRITIQUES "...a solid, authoritative resource."--New Hampshire Nurses Association Touch has received increased attention over the last few decades, with growing recognition of its profound import to all facets of life. The Handbook of Touch is the first authoritative, state-of-the-art resource for scientists, scholars, and students interested in the neurobehavioral foundations of touch and its many applications. This text provides an in-depth overview of the conceptual and empirical scope of the field. Chapters are written by a cadre of internationally known experts on touch, representing an expansive breadth of knowledge from behavioral, health, and neuroscience disciplines. Key Features: Integrates knowledge regarding the neurobiology of touch, covering the spectrum from skin physiology and somatosensory pathways to touch-related genes and proteins Synthesizes research about the neural processing and perception of touch Describes diverse methods for measuring touch behavior and human response to touch Discusses the role of touch in social communication, along with the influence of context and culture Presents cutting edge research that links touch to brain organization and plasticity, human development, and varied dimensions of health