Programmed Cell Death In Cancer Progression And Therapy

Author: Roya Khosravi-Far
Publisher: Springer Science & Business Media
ISBN: 9781402065545
Size: 76.74 MB
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Programmed Cell Death In Cancer Progression And Therapy from the Author: Roya Khosravi-Far. Programmed cell death (PCD) plays pivotal roles in tumor progression, cancer therapeutics and resistance of tumor cells to therapy. This book examines the mechanisms involved in mediating and regulating PCD in cancer. It also provides a detailed indication of the utility of PCD in cancer therapy. The book features chapters on the current and future of RNA interference in therapeutics and Pathways involved in Stem Cell Survival and Death.

The Handbook Of Jungian Play Therapy With Children And Adolescents

Author: Eric J. Green
Publisher: JHU Press
ISBN: 1421415119
Size: 32.96 MB
Format: PDF, ePub, Docs
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The Handbook Of Jungian Play Therapy With Children And Adolescents from the Author: Eric J. Green. Child and family psychotherapist Eric J. Green draws on years of clinical experience to explain his original model of Jungian play therapy. The empathic techniques he illuminates in The Handbook of Jungian Play Therapy with Children and Adolescents can effectively treat children who are traumatized by abuse, natural disasters, and other losses, as well as children who have attention deficit and autism spectrum disorders. The overarching goal of Green’s Jungian play therapy model is to help children and adolescents become psychologically whole individuals. Toward that end, therapists encourage children to engage in sandplay, spontaneous drawing, and other expressive arts. Green demonstrates how therapists can create an atmosphere of warmth and psychological safety by observing the child’s play without judgment and, through the therapeutic relationship, help children learn to regulate their impulses and regain emotional equilibrium. Designed for master’s level and doctoral students, as well as school counselors, play therapists, and private practitioners, the book covers the theoretical underpinnings of "depth psychology" while highlighting easy-to-understand case studies from Green’s own practice to illustrate Jungian play therapy applications at work. -- Charles E. Schaefer, Co-founder and Director Emeritus of the Association for Play Therapy, Clovis, CA

Death Receptors In Cancer Therapy

Author: Wafik S. El-Deiry
Publisher: Springer Science & Business Media
ISBN: 159259851X
Size: 19.19 MB
Format: PDF
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Death Receptors In Cancer Therapy from the Author: Wafik S. El-Deiry. An in depth review of our latest understanding of the molecular events that regulate cell death and those molecules that provide targets for developing agonists or antagonists to modulate death signaling for therapeutic purposes. The authors focus on the extrinsic system of death receptors, their regulation and function, and their abnormalities in cancer. Topics of particular interest include resistance to apoptosis, TRAIL signaling, death receptors in embryonic development, mechanisms of caspase activation, and death receptor mutations in cancer. Additional chapters address death signaling in melanoma, synthetic retinoids and death receptors, the role of p53 in death receptor regulation, immune suppression of cancer, and combination therapy with death ligands.

Radiation Therapy Of Benign Diseases

Author: Stanley E. Order
Publisher: Springer Science & Business Media
ISBN: 9783540005759
Size: 16.95 MB
Format: PDF, ePub
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Radiation Therapy Of Benign Diseases from the Author: Stanley E. Order. This expanded and updated second edition is a practical text to aid radiation oncologists in evaluating and treating benign diseases. An introductory chapter by an eminent malpractice lawyer clarifies the medical-legal implications of the radiation treatment of such diseases, and this is followed by the various benign conditions in alphabetical order. In each case, a brief summary is followed by citations of pertinent literature in both explanatory tables and reference lists. Although a comprehensive review, it remains readily comprehensible and will be recognised as the standard text on the subject.

Biology Driven Targeted Therapy Of Pediatric Soft Tissue And Bone Tumors Current Opportunities And Future Challenges

Author: Thomas G. P. GrĂĽnewald
Publisher: Frontiers Media SA
ISBN: 2889198197
Size: 72.43 MB
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Biology Driven Targeted Therapy Of Pediatric Soft Tissue And Bone Tumors Current Opportunities And Future Challenges from the Author: Thomas G. P. Grünewald. Recent advances in the understanding of the biological basis of pediatric soft-tissue and bone tumors, especially owing to the advent of “omics” technologies, have led to an exponential increase in the current knowledge on the genetic and cellular patho-mechanisms that drive these diseases. This offers the unprecedented opportunity to develop and implement targeted therapies such as monoclonal antibodies, small molecules, oncolytic viruses, and immunotherapies in standard and/or personalized treatment regimens. However, to date only a few examples document a successful translation of discoveries from the bench to the bedside. Recent international expert congresses further emphasize the urgent need for a more rapid and especially more successful translational process. Hence, we strongly believe that a Frontiers Research Topic aiming at this aspect would fit just in time and be relevant for a broad readership. This Frontiers Research Topic intended to provide a platform for active and interdisciplinary discussion, to summarize current state-of-the-art knowledge on all basic research and translational aspects in pediatric soft-tissue and bone tumors, and to offer new perspectives on how to further promote and accelerate the translational process. It comprises high-quality original articles and timely reviews.

Tumors Of The Central Nervous System Volume 2

Author: M.A. Hayat
Publisher: Springer Science & Business Media
ISBN: 9789400706187
Size: 52.26 MB
Format: PDF, ePub, Mobi
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Tumors Of The Central Nervous System Volume 2 from the Author: M.A. Hayat. Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained.

Lipid Lowering Therapy And Progression Of Coronary Atherosclerosis

Author: A.V. Bruschke
Publisher: Springer Science & Business Media
ISBN: 9400901437
Size: 63.62 MB
Format: PDF, Kindle
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Lipid Lowering Therapy And Progression Of Coronary Atherosclerosis from the Author: A.V. Bruschke. A unique overview of all major angiographic lipid intervention trials, presented by their principal investigators. Basic mechanisms and methodological aspects, including biochemical as well as angiographic aspects, are discussed by experts in these fields. A careful comparison of all available data permits an analysis to be made of what may currently be considered proved, which aspects merit further investigation, and which hypotheses should be rejected. Audience: Clinicians involved in the practice of lipid lowering and investigators involved in lipid-lowering clinical trials. Scientists involved in other areas of lipid research and investigators conducting coronary angiographic trials designed to study the influence of different interventions will find a wealth of information and practical guidelines in this book.

Cases In Cardiac Resynchronization Therapy E Book

Author: Cheuk-Man Yu
Publisher: Elsevier Health Sciences
ISBN: 1455737399
Size: 43.20 MB
Format: PDF, Kindle
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Cases In Cardiac Resynchronization Therapy E Book from the Author: Cheuk-Man Yu. Cases in Cardiac Resynchronization Therapy, a brand-new medical reference book for cardiologists, electrophysiologists, surgeons, and primary care doctors, offers an informative and structured view of the newest approaches, treatments and follow-up care methods for heart failure patients treated with Cardiac Resynchronization Therapy. Complete with practical examples from top leaders in the field, this resource is designed to equip you with the cohesive, expert knowledge you need to make the best use of today's available technologies and research. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Better manage the challenging clinical scenarios you may encounter with case studies that include a brief introduction, clinical decision-making techniques, evidence-based rationales, and selected references for further study. Remain up-to-date in this rapidly evolving field with clinical recommendations, updates on the latest technological advances, troubleshooting techniques, and recent key clinical trials. Access practical examples regarding the process for selecting and implanting devices, as well as follow-up care for heart-failure patients being treated with CRT. Stay abreast of today's novel wireless technologies, information on robotic-assisted implantations, and current methodologies on VV optimization.

Therapy Of Skin Diseases

Author: Thomas Krieg
Publisher: Springer Science & Business Media
ISBN: 9783540788140
Size: 80.35 MB
Format: PDF, ePub, Mobi
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Therapy Of Skin Diseases from the Author: Thomas Krieg. Based on the understanding of the molecular basis of skin diseases, this truly international book supports the reader to understand the mode of action of new and established therapies. Thus, by explaining the molecular pathology with its applications for therapy, it provides the reader with an up-to-date knowledge of the therapy of skin disease and helps to understand ongoing and new developments in the field. Written and edited by international and renowned dermatology experts from Europe, America and Asia, it also includes regional concepts of therapies. The reader-friendly structure allows the reader to pick up the information quickly; for example, each chapter highlights practical hints for indications and applications. This lavishly illustrated book will support the reader to choose the most appropriate therapy for the patient and to reach a better treatment outcome. It will be an indispensable resource for dermatologists in university departments as well as in clinical practice.