Cytogenetic Abnormalities

Author: S. Zneimer
Publisher: John Wiley & Sons
ISBN: 1118412567
Size: 32.97 MB
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Cytogenetic Abnormalities from the Author: S. Zneimer. This guide discusses chromosomal abnormalities and how best to report and communicate lab findings in research and clinical settings. Providing a standard approach to writing cytogenetic laboratory reports, the guide further covers useful guidance on implementing International System for Human Cytogenetic Nomenclature in reports. Part one of the guide explores chromosomal, FISH, and microarray analysis in constitutional cytogenetic analyses, while part two looks at acquired abnormalities in cancers. Both sections provide illustrative examples of chromosomal abnormalities and how to communicate these findings in standardized laboratory reports.

Mechanisms Of Oncogenesis

Author: Domenico Coppola
Publisher: Springer Science & Business Media
ISBN: 9789048137251
Size: 28.76 MB
Format: PDF, Docs
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Mechanisms Of Oncogenesis from the Author: Domenico Coppola. This book offers a comprehensive update on mechanisms of tumorigenesis. The first portion discusses pediatric cancer, the influence of environmental factors and oncogene activity in tumorigenesis; the second portion is structured by organ site for easy access.

Human Cytogenetics Malignancy And Acquired Abnormalities

Author: Denise E. Rooney
Publisher: Oxford University Press, USA
ISBN: 9780199638413
Size: 63.14 MB
Format: PDF
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Human Cytogenetics Malignancy And Acquired Abnormalities from the Author: Denise E. Rooney. The advent of molecular technologies has lead to a rapid acceleration in the cytogenetic study of malignancy and acquired abnormalities. As well as having a chapter devoted to molecular technologies (FISH, PRINS, and CGH), molecular methodology is emphasized in all chapters, for example the role of CGH in solid tumour cytogenetics. Classical techniques are not forgotten, with a detailed description of the preparation and analysis of chromosomes from bone marrow and leukaemic blood. This is followed by three chapters on the specific methodology for the cytogenetic study of myeloid leukaemia, acute lymphoblastic leukaemia, and lymphomas and lymphoproliferative disorders. Also covered are chromosome instability syndromes, mutagen-induced chromosome damage in lymphocytes and the role of cytogenetics in the assessment of haematological disorders. This book will be invaluable to any scientists using cytogenetics to study malignancy and along with its sister volume Human Cytogenetics: Constitutional Analysis will be an essential purchase for any cytogenetics laboratory. The volumes are available individually or as a set.

Leukemias

Author: Stefan Faderl
Publisher: John Wiley & Sons
ISBN: 1444347810
Size: 29.45 MB
Format: PDF, ePub
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Leukemias from the Author: Stefan Faderl. Edited by experts from one of the world’s largest leukemia centers, this book provides information on the biology of the variety of leukemic disorders, up-to-date diagnostic testing and many new developments in therapy. Chapters covering new treatments present an outlook for the future and explain the rationale for ongoing clinical trials. Topics include: Targeted therapy, e.g. tyrosine kinase inhibitors (Flt3, Aurora kinase inhibitors, kit inhibitors, BCR-ABL inhibitors) Ras inhibitors Epigenetic therapy (hypomethylaters and histone deacetylase inhibitors) Lenalidomide analogs New chemotherapy drugs, e.g. clofarabine, cloretazine, sapacitabine, forodesine Combinations of chemotherapy with kinase inhibitors (e.g. ALL induction protocols in combination with dasatinib or imatinib) New monoclonal antibodies (lumiliximab, humaxCD20, anti-CD40) Thrombopoietic agents Leukemias: Principles and Practice of Therapy Includes practical information to guide you in challenging situations, such as treatment of elderly patients, pregnancy, relapsed and refractory disease Incorporates chapters on supportive care and pharmacologic information about the most frequently used drugs in this area

Human Cytogenetic Cancer Markers

Author: Sandra R. Wolman
Publisher: Springer Science & Business Media
ISBN: 1461239524
Size: 23.79 MB
Format: PDF, ePub
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Human Cytogenetic Cancer Markers from the Author: Sandra R. Wolman. Seventeen cutting-edge chapters review both basic research and clinical applications of chromosomal markers of cancer. The new markers offer great promise, not only for their clinical utility in diagnosis, prognosis, and disease monitoring, but also for their contributions to a better understanding of the mechanisms of tumor development and progression. The chapters-all written by leading authorities-skillfully reveal fresh insights into the translational role of cytogenetics in identifying the cellular and molecular changes that occur in cancer. Coverage is devoted to many tissue systems-colon, breast, prostate, lung, skin, brain, and kidney-where the diagnostic and prognostic utility of chromosome markers is clearly demonstrated. A seminal book certain to become the front-line reference and authoritative resource needed by all scientists and clinicians engaged in cancer research, diagnosis, and management.

Wintrobe S Atlas Of Clinical Hematology

Author: Douglas C. Tkachuk
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781770231
Size: 67.64 MB
Format: PDF, Kindle
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Wintrobe S Atlas Of Clinical Hematology from the Author: Douglas C. Tkachuk. Featuring over 400 brilliantly sharp, high-resolution diagnostic digital photomicrographs combined with concise, clinically oriented text, this full-color atlas is a comprehensive pictorial guide to diagnostic hematology. Tied to the world-renowned textbook Wintrobe's Clinical Hematology, this brand-new atlas enables physicians to see and readily comprehend diseased tissues and understand the complex assays used in patient care. The comprehensive pictorial collection covers all hematologic diseases and includes relevant clinical and radiological images, photomicrographs (surgical and autopsy specimens), and advanced diagnostic laboratory images including molecular assays, FISH, and cytogenetics. The color pictures are combined with diagrams and tables that help readers use "algorithmic" approaches to diagnosis. Two complementary formats allow readers to approach hematologic diseases from either Wintrobe's disease categorization perspective, or by an image-directed approach based on morphological pattern recognition in diseased tissues. A bound-in DVD contains large high-resolution photomicrographs, digitally enhanced to allow readers to interact with components of the print image.

Manual Of Cytogenetics In Reproductive Biology

Author: Pankaj Talwar
Publisher: JP Medical Ltd
ISBN: 9350909928
Size: 55.92 MB
Format: PDF, Docs
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Manual Of Cytogenetics In Reproductive Biology from the Author: Pankaj Talwar. Examines the diagnostic role of cytogenetics in improving the outcome of assisted reproductive technologies (ART). Covers basics of genetics, followed by investigative cytogenetics, applied cytogenetics, recent advances, preimplantation and prenatal cytogenetics.

The Principles Of Clinical Cytogenetics

Author: Steven Gersen
Publisher: Springer Science & Business Media
ISBN: 1592598331
Size: 46.52 MB
Format: PDF, Docs
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The Principles Of Clinical Cytogenetics from the Author: Steven Gersen. This thoroughly revised and expanded edition of a highly praised classic, The Principles of Clinical Cytogenetics, includes the many advances that have occurred in the field. Among the highlights are a full section devoted to advances in fluorescence in situ hybridization (FISH) technology, increased coverage of cancer cytogenetics-both hematopoietic neoplasms and tumor cytogenetics-and new chapters on chromosome instability and the cytogenetics of infertility. The book offers physicians who depend on the cytogenetics laboratory for the diagnosis of their patients, students in cytogenetics programs, and cytogeneticists the clear understanding they need to carry out and interpret their test results rapidly.

Renal Cell Carcinoma

Author: Brian I. Rini
Publisher: PMPH-USA
ISBN: 9781607950035
Size: 25.42 MB
Format: PDF, Mobi
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Renal Cell Carcinoma from the Author: Brian I. Rini. Edited and written by medical oncologists and surgeons, this new reference covers all aspects of renal cell cancer from pathology and molecular genetics onto diagnosis, screening and imaging. Includes all the latest on management and treatment from medical and immunotherapy through to surgical procedures. Covers future therapeutics and supportive care. The bulk of the chapters deal with practical management of the continuum of kidney cancer ranging from the small renal mass to the metastatic patient. Different treatment approaches are discussed within the context of each of these clinical scenarios and surgical and therapeutic advances are highlighted. In addition, special populations such as patients requiring palliative care, those with brain or bone metastasis and those with inherited renal cell carcinoma are discussed.

Perry S The Chemotherapy Source Book

Author: Michael Clinton Perry
Publisher: Lippincott Williams & Wilkins
ISBN: 1451101457
Size: 48.85 MB
Format: PDF, Mobi
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Perry S The Chemotherapy Source Book from the Author: Michael Clinton Perry. Perry's The Chemotherapy Source Book, now in its fifth edition, provides information on the choice of chemotherapeutic agents, the use of combination chemotherapy, and the toxicity of individual drugs. Organized by site, this is the only book of its kind to focus strictly on the clinical practice of chemotherapy, and is meant to serve as a “one-stop shop” for information on choice of chemotherapeutic agents, treatment outlines, grading of side effects, and dose modification.