Chemistry Of Metalloproteins

Author: Joseph J. Stephanos
Publisher: John Wiley & Sons
ISBN: 1118801520
Size: 45.68 MB
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Chemistry Of Metalloproteins from the Author: Joseph J. Stephanos. Addresses the full gamut of questions in metalloprotein science Formatted as a question-and-answer guide, this book examines all major families of metal binding proteins, presenting our most current understanding of their structural, physicochemical, and functional properties. Moreover, it introduces new and emerging medical applications of metalloproteins. Readers will discover both the underlying chemistry and biology of this important area of research in bioinorganic chemistry. Chemistry of Metalloproteins features a building block approach that enables readers to master the basics and then advance to more sophisticated topics. The book begins with a general introduction to bioinorganic chemistry and metalloproteins. Next, it covers: Alkali and alkaline earth cations Metalloenzymes Copper proteins Iron proteins Vitamin B12 Chlorophyll Chapters are richly illustrated to help readers fully grasp all the chemical concepts that govern the biological action of metalloproteins. In addition, each chapter ends with a list of suggested original research articles and reviews for further investigation of individual topics. Presenting our most current understanding of metalloproteins, Chemistry of Metalloproteins is recommended for students and researchers in coordination chemistry, biology, and medicine. Each volume of the Wiley Series in Protein and Peptide Science addresses a specific facet of the field, reviewing the latest findings and presenting a broad range of perspectives. The volumes in this series constitute essential reading for biochemists, biophysicists, molecular biologists, geneticists, cell biologists, and physiologists as well as researchers in drug design and development, proteomics, and molecular medicine with an interest in proteins and peptides.


Author: Art E. Cho
Publisher: CRC Press
ISBN: 1439813191
Size: 64.50 MB
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Metalloproteins from the Author: Art E. Cho. Numerous essential biological functions involve metalloproteins; therefore, understanding metalloproteins and how to manipulate them is significant in the biological and medical fields. An examination of current research, Metalloproteins: Theory, Calculations, and Experiments explores the interplay between theory and experiment, detailing the role of theoretical modeling in the field and explaining how it aids experiments. The text also presents the current state of computational protein modeling, enabling researchers to adopt computation as an integral component of their studies. This book addresses two different aspects on metalloproteins in unison. It reviews the development of theoretical and computational methods for metalloprotein simulation with specific examples. The authors also present some of the most intriguing and important experimental results on metalloprotein systems. Although a connection can be made between these two aspects of the research, the authors do not do so explicitly. Rather, they provide the platform required to ignite further collaboration between experimentalists and theoreticians. A collection of works from top researchers in this field, the text presents diverse subjects that comprehensively reflect the current state of metalloprotein research. With these advances in structural information, theory and computation are starting to play a more significant role, particularly in identifying the reaction mechanism. The book summarizes some of the recent progress in both experiments and theory/computation showing the synergy that is now developing.

Handbook Of Metalloproteins Volumes 4 5

Author: Albrecht Messerschmidt
Publisher: Wiley-Blackwell
ISBN: 9780470711996
Size: 34.98 MB
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Handbook Of Metalloproteins Volumes 4 5 from the Author: Albrecht Messerschmidt. Highlights the progress made in finding new and exciting metalloproteins 10 years after the original publication of the Handbook of Metalloproteins Volumes 1 & 2, and following publication of Volume 3 in 2004, comes the latest two volumes... Presents detailed descriptions of the most exciting newly discovered metalloproteins, including: New metalloproteins involved in photosynthesis, e.g. photosystem I and II, cytochromes New Copper Metalloproteins involved in the formation of Alzheimer’s disease and are leads to new medication New metalloproteins essential in understanding the function of nerves and muscles Researching the structure and function of metalloproteins is one of the biggest challenges in modern biological chemistry – and several Nobel Prizes have been awarded to research in the field, including to the Co-Editor Robert Huber in 1988. Volumes 4 & 5 help bring together the very latest new and exciting metalloproteins in two volumes to help keep you up-to-date in this continually expanding field, including: New metalloproteins involved in photosynthesis Photosynthesis is vital for life on earth. Contributions on photosystem I and II as well as on cytochrome b6f, which are main components of the oxygenic photosynthetic machinery in plants, algae and cyanobacteria, unravel the role of metals and metal cofactors in this fascinating fundamental process New Copper Metalloproteins The role of copper in connection with the amyloid precursor protein for Alzheimer’s disease New metalloproteins essential in understanding the function of nerves and muscles Contributions on Mg2+, Na+ and K+ channels/transporters have been included to highlight their formidable significance in biological systems. Na+, K+-ATPase is e.g. very abundant in heart muscle tissues and represents the target for drugs against heart insufficiency like digitalis drugs Metalloproteins used in metal ion transport and storage Metal ion transport, storage and incorporation have been deeper considered in a row of new articles. The metal ions include iron, zinc, nickel and copper. Factor VIII Factor VIII is an essential blood clotting factor. Some defects might cause a lack of this factor and result in hemophelia A. The new two volumes contain articles published online in the Handbook of Metalloproteins (HMET) from 2007 – 2010, these cover a wide range of newly discovered and exciting metalloproteins since publication of HMET in 2006. These new additional volumes will provide essential reading to all experienced researchers in bioinorganic chemistry and should give the newcomer a good entry into the field in the following areas: Metalloproteins, Proteins, Proteomics, Coordination Chemistry, Bioinorganic Chemistry, Biochemistry, Drug Development, Enzymology.

Electrons Atoms And Molecules In Inorganic Chemistry

Author: Joseph J. Stephanos
Publisher: Academic Press
ISBN: 012811049X
Size: 55.21 MB
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Electrons Atoms And Molecules In Inorganic Chemistry from the Author: Joseph J. Stephanos. Electrons, Atoms, and Molecules in Inorganic Chemistry: A Worked Examples Approach builds from fundamental units into molecules, to provide the reader with a full understanding of inorganic chemistry concepts through worked examples and full color illustrations. The book uniquely discusses failures as well as research success stories. Worked problems include a variety of types of chemical and physical data, illustrating the interdependence of issues. This text contains a bibliography providing access to important review articles and papers of relevance, as well as summaries of leading articles and reviews at the end of each chapter so interested readers can readily consult the original literature. Suitable as a professional reference for researchers in a variety of fields, as well as course use and self-study. The book offers valuable information to fill an important gap in the field. Incorporates questions and answers to assist readers in understanding a variety of problem types Includes detailed explanations and developed practical approaches for solving real chemical problems Includes a range of example levels, from classic and simple for basic concepts to complex questions for more sophisticated topics Covers the full range of topics in inorganic chemistry: electrons and wave-particle duality, electrons in atoms, chemical binding, molecular symmetry, theories of bonding, valence bond theory, VSEPR theory, orbital hybridization, molecular orbital theory, crystal field theory, ligand field theory, electronic spectroscopy, vibrational and rotational spectroscopy

Bioorganometallic Chemistry

Author: GĂ©rard Jaouen
Publisher: John Wiley & Sons
ISBN: 3527335277
Size: 55.68 MB
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Bioorganometallic Chemistry from the Author: GĂ©rard Jaouen. An up-to-date reference reflecting the significant advances and important breakthroughs made in this emerging discipline over the last decade. As such, the book provides an overview of the latest developments and future trends in the field, focusing on such applications as the development of potentially active organometallic drugs against incurable diseases, as well as in such areas as catalysis, energy, analytical chemistry, and imaging. The renowned editor, who established the term "bioorganometallics", and his international team of experts have put together a valuable resource for researchers in organometallic, inorganic, medicinal, and biochemistry.

Handbook On Metalloproteins

Author: Ivano Bertini
Publisher: CRC Press
ISBN: 9780824705206
Size: 14.69 MB
Format: PDF, ePub
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Handbook On Metalloproteins from the Author: Ivano Bertini. This Handbook on Metalloproteins focuses on the available structural information of proteins and their metal ion coordination spheres. It centers on the metal ions indispensable for life but also considers metal ions used as substitution probes in studies of metalloproteins. Emphasizing the structure-function relationship, the book covers the common and distinct characterstics of metallo- enzymes, proteins, and amino acids bonded to copper, zinc, iron, and more.

Metalloproteins Advances In Research And Application 2013 Edition

Publisher: ScholarlyEditions
ISBN: 1490102043
Size: 24.38 MB
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Metalloproteins Advances In Research And Application 2013 Edition from the Author: . Metalloproteins—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Hemocyanin. The editors have built Metalloproteins—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Hemocyanin in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Metalloproteins—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Ligand Design In Medicinal Inorganic Chemistry

Author: Tim Storr
Publisher: John Wiley & Sons
ISBN: 1118697898
Size: 15.66 MB
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Ligand Design In Medicinal Inorganic Chemistry from the Author: Tim Storr. Increasing the potency of therapeutic compounds, while limiting side-effects, is a common goal in medicinal chemistry. Ligands that effectively bind metal ions and also include specific features to enhance targeting, reporting, and overall efficacy are driving innovation in areas of disease diagnosis and therapy. Ligand Design in Medicinal Inorganic Chemistry presents the state-of-the-art in ligand design for medicinal inorganic chemistry applications. Each individual chapter describes and explores the application of compounds that either target a disease site, or are activated by a disease-specific biological process. Ligand design is discussed in the following areas: Platinum, Ruthenium, and Gold-containing anticancer agents Emissive metal-based optical probes Metal-based antimalarial agents Metal overload disorders Modulation of metal-protein interactions in neurodegenerative diseases Photoactivatable metal complexes and their use in biology and medicine Radiodiagnostic agents and Magnetic Resonance Imaging (MRI) agents Carbohydrate-containing ligands and Schiff-base ligands in Medicinal Inorganic Chemistry Metalloprotein inhibitors Ligand Design in Medicinal Inorganic Chemistry provides graduate students, industrial chemists and academic researchers with a launching pad for new research in medicinal chemistry.

Brain Diseases And Metalloproteins

Author: David R. Brown
Publisher: CRC Press
ISBN: 981436407X
Size: 11.93 MB
Format: PDF
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Brain Diseases And Metalloproteins from the Author: David R. Brown. This book describes the latest research on neurodegenerative disease and metal-binding proteins. It lays strong emphasis on biochemistry and cell biology. The diseases covered in the book include Parkinson’s disease, Alzheimer’s disease, prion disease, and ALS. The chapters separately examine such issues as mechanisms of metal binding, metal-induced structural changes in proteins, alterations in cellular metal metabolism in disease, and attempts at a therapeutic approach based on protein metal binding.