Autophagy Cancer Other Pathologies Inflammation Immunity Infection And Aging

Author: M. A. Hayat
Publisher: Academic Press
ISBN: 0128010541
Size: 64.38 MB
Format: PDF
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Autophagy Cancer Other Pathologies Inflammation Immunity Infection And Aging from the Author: M. A. Hayat. Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst inciting researchers to explore their potentially important connections. Volume 5 comprehensively describes the role of autophagy in human diseases, delivering coverage of the antitumor and protumor roles of autophagy; the therapeutic inhibition of autophagy in cancer; and the duality of autophagy’s effects in various cardiovascular, metabolic, and neurodegenerative disorders. In spite of the increasing importance of autophagy in the various pathophysiological conditions mentioned above, this process remains underestimated and overlooked. As a consequence, its role in the initiation, stability, maintenance, and progression of these and other diseases remains poorly understood. This book is an asset to newcomers as a concise overview of the diverse disease implications of autophagy, while serving as an excellent reference for more experienced scientists and clinicians looking to update their knowledge. Volumes in the Series

Oxidative Stress And Inflammation In Non Communicable Diseases Molecular Mechanisms And Perspectives In Therapeutics

Author: Jordi Camps
Publisher: Springer
ISBN: 3319073206
Size: 48.90 MB
Format: PDF, ePub, Mobi
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Oxidative Stress And Inflammation In Non Communicable Diseases Molecular Mechanisms And Perspectives In Therapeutics from the Author: Jordi Camps. Oxidative stress and inflammation underpin most diseases; their mechanisms are inextricably linked. For example, chronic inflammation is associated with oxidation, anti-inflammatory cascades are linked to decreased oxidation, increased oxidative stress triggers inflammation and redox balance inhibits the inflammatory cellular response. Whether or not oxidative stress and inflammation represent the causes or the consequences of cellular pathology, they contribute significantly to the pathogenesis of non-communicable diseases. The incidence of obesity and other related metabolic disturbances are rising, as are age-related diseases due to progressively aging populations. Interrelations between the mechanisms of oxidative stress and of inflammatory signaling and metabolism are, in the broad sense of energy transformation, being increasingly recognized as part of the problem in non-communicable diseases. The book Oxidative Stress and Inflammation in Non-communicable Diseases: Molecular Mechanisms and Perspectives in Therapeutics is an update on the latest research on the molecular basis of non-communicable diseases and the search for possible therapeutic alternatives. The authors of this monograph are experts in their field and the book as a whole, provides an overview of the biochemical alterations underlying diseases such as cardiovascular disease, cancer, obesity, renal disease, neurological diseases and diabetes, emphasizing those aspects that they share in common. We hope that this book will be useful for researchers in biomedicine and also for physicians interested in finding the root causes of the disease, as well as for post-graduate students in biochemistry, molecular biology, nutrition or medicine.

The Aging Lungs

Author: Richard Bucala
Publisher: World Scientific
ISBN: 9814635022
Size: 24.54 MB
Format: PDF, ePub, Mobi
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The Aging Lungs from the Author: Richard Bucala. This volume provides a comprehensive and multi-disciplinary overview of the aging lung, written by the main researchers in the field. Current physiological, cellular and molecular understanding of how the lungs age and the relationship to age-associated lung diseases will be presented. The contents are aimed at a broad audience of scientists and clinicians with an interest in the respiratory system, pathogenesis of age-associated lung diseases and clinical implications. Contents:Normal Development, Anatomy, Histology and Aging of the Lung (Xuchen Zhang and Robert J Homer)Physiology of the Aging Lung (Brienne Miner, Thomas M Gill, and Carlos A Vaz Fragoso)Aging Lung, Environmental and Genetic Factors — Race, Ethnicity and Gender (Holly Keyt, Stephanie Levine, and Claude Jourdan Le Saux)Frailty in Pulmonary and Critical Care Medicine (Cristine E Berry and Enid R Neptune)Intensive Care Unit Outcomes in Older Adults (Margaret A Pisani and Lauren Ferrante)Severe Sepsis, Pneumonia and Aging (Olufunmilayo Falade and Sachin Yende)Sepsis and Acute Lung Injury in Aging (Anup Srivastava, Yao Wong, Shruti Erramilli, and Praveen Mannam)Acute Respiratory Distress Syndrome: The Role of Mesenchymal Stem Cells and Arising Complications Due to an Aging Lung (John Sembrat, Maria G Kapetanaki, and Mauricio Rojas)The Aging Immune System, Vaccine Efficacy, and the Lung (Jenna M Bartley and Laura Haynes)Respiratory Infection, Airway Colonization and Chronic Inflammation in Aging (Chad Marion and Charles S Dela Cruz)HIV, the Lung and Aging (Lynn M Schnapp and Kristina Crothers)Geriatric Pulmonary Hypertension: Recent Epidemiologic Trends and Treatment Update (Vanessa Yap, George A Kuchel, and Raymond J Foley)Growth Factors and Aging in Pulmonary Arterial Hypertension (Claudio Bravo, Won-Kyung Cho, and Hyung J Chun)Chronic Obstructive Lung Disease in the Elderly (Jessica F Most and Carolyn L Rochester)Genomics of Lung Aging and Idiopathic Pulmonary Fibrosis (Brenda Juan-Guardela and Naftali Kaminski)Potential Mechanistic Links Between Aging and IPF (Hongyi Pan, Mridu Gulati, and Erica L Herzog)Telomeres and Telomerase (Mary Armanios)Endoplasmic Reticulum Stress (Marta Bueno and Ana L Mora)Autophagy and Metabolism (Jaime L Schneider and Cecilia G Sanchez) Readership: Graduate and post-graduate respiratory, pulmonary, thoracic scientists and physicians; Clinical researchers interested in both pulmonary and aging issues, medical students and professionals. Key Features:Pre-eminent authors and researchers in their respective fieldsComprehensive coverage of research, clinical and therapeutic considerationsCutting-edge biology and mechanisms includedKeywords:Lungs;Aging;Senescence;COPD;Fibrosis;Asthma;Pulmonary Vascular Diseases

Retina

Author: Stephen J. Ryan
Publisher: Elsevier Health Sciences
ISBN: 1455737801
Size: 58.15 MB
Format: PDF, Docs
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Retina from the Author: Stephen J. Ryan. Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today’s new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you're using or where you're located. Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard. Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia, and the Americas. Make the best use of new technologies with expanded and updated coverage of optical coherence tomography (OCT), fundus imaging, and autofluorescence imaging. Apply the latest knowledge on anti-VEGF therapy for age related macular degeneration, diabetic retinopathy and vein disease. Learn about artificial vision, drug delivery to the posterior segment, advances in macular surgery, vitrectomy, and complex retinal detachment, with updates on tumors, retinal genetics, cell biology, important basic science topics, and much more. Get the most out of new pharmacologic approaches in the management of age-related macular degeneration and diabetic retinopathy. In your practice, diagnostic evaluations, and now even treatments, will be influenced by recent scientific discoveries such as in the areas of nanotechnology, neuro protection, stem cells and gene therapy, among other scientific contributions. View videos of surgical procedures and access the complete contents of Retina, 5th Edition online at www.expertconsult.com, fully searchable, with regular updates and a downloadable image gallery.

Life Extension

Author: Alexander Vaiserman
Publisher: Springer
ISBN: 3319183265
Size: 31.50 MB
Format: PDF, ePub, Docs
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Life Extension from the Author: Alexander Vaiserman. ​This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.

The Aging Clock

Author: Walter Pierpaoli
Publisher:
ISBN: 9780897668606
Size: 10.29 MB
Format: PDF, ePub, Mobi
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The Aging Clock from the Author: Walter Pierpaoli. The pineal is regarded as an ontogenic and evolutionary point of departure for research on the causes of senescence, suppported by in vivo experimental evidence, such as pineal cross-transplantation. Among the findings reported here, that reinforce the concept of the central clock, is the unique ability of melatonin to keep dangerous hydroxyl radicals under control. In addition, studies on the effect of caloric restriction and nutritional factors are building blocks in the understanding of how and why we age and develop cancer, together with other studies such as: the role of ubiquitous zinc and of extra-pineal melatonin; the disruption of biological rhythms; ultra-structure in brain diseases and dementia; the transacting factors as key regulatory proteins that mediate families of stress response genes; the aging antigen; the mother steroid DHEA during aging; the role of protein kinase C; the loss of D2 dopamine receptors during aging; brain amyloid formation; the role of cell cycles and cyclic AMP; the pineal peptides; and the decay of central neuro-endocrine-immune functions during aging.

Philosophical Transactions

Author:
Publisher:
ISBN:
Size: 73.60 MB
Format: PDF
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Philosophical Transactions from the Author: . Each issue of Transactions B is devoted to a specific area of the biological sciences, including clinical science. All papers are peer reviewed and edited to the highest standards. Published on the 29th of each month, Transactions B is essential reading for all biologists.

Issues In Geriatric Medicine And Aging Research 2011 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 146496498X
Size: 13.79 MB
Format: PDF, Kindle
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Issues In Geriatric Medicine And Aging Research 2011 Edition from the Author: . Issues in Geriatric Medicine and Aging Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Geriatric Medicine and Aging Research. The editors have built Issues in Geriatric Medicine and Aging Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Geriatric Medicine and Aging Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Geriatric Medicine and Aging Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Cancer New Insights For The Healthcare Professional 2011 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 1464900027
Size: 33.90 MB
Format: PDF, Mobi
View: 5827
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Cancer New Insights For The Healthcare Professional 2011 Edition from the Author: . Cancer: New Insights for the Healthcare Professional: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cancer. The editors have built Cancer: New Insights for the Healthcare Professional: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cancer in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cancer: New Insights for the Healthcare Professional: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues In Life Sciences Cellular Biology 2011 Edition

Author:
Publisher: ScholarlyEditions
ISBN: 146496386X
Size: 73.29 MB
Format: PDF
View: 2867
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Issues In Life Sciences Cellular Biology 2011 Edition from the Author: . Issues in Life Sciences: Cellular Biology / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Life Sciences—Cellular Biology. The editors have built Issues in Life Sciences: Cellular Biology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Life Sciences—Cellular Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences: Cellular Biology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.