A Pharmacology Primer

Author: Terry Kenakin
Publisher: Academic Press
ISBN: 9780080465302
Size: 11.56 MB
Format: PDF, Kindle
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A Pharmacology Primer from the Author: Terry Kenakin. The Second Edition will continue this tradition of better preparing researchers in the basics of pharmacology. In addition, new human interest material including historical facts in pharmacology will be added. A new section on therapeutics will help readers identify with diseases and drug treatments. Over 30 new figures and tables More human interest information to provide readers with historical facts on pharmacology research New section on therapeutics to help identify diseaes and drug treatments New section on new biological concepts relevant to pharmacological research (i.e., systems biology) New study sections organized with ASPET and other international pharmacology organizations New coverage of pharmacokinetics and drug disposition

The Handbook Of Medicinal Chemistry

Author: Andrew Davis
Publisher: Royal Society of Chemistry
ISBN: 1782621830
Size: 44.74 MB
Format: PDF, Kindle
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The Handbook Of Medicinal Chemistry from the Author: Andrew Davis. Drug discovery is a constantly developing and expanding area of research. Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry covers the past, present and future of the entire drug development process. Highlighting the recent successes and failures in drug discovery, the book helps readers to understand the factors governing modern drug discovery from the initial concept through to a marketed medicine. With chapters covering a wide range of topics from drug discovery processes and optimization, development of synthetic routes, pharmaceutical properties and computational biology, the handbook aims to enable medicinal chemists to apply their academic understanding to every aspect of drug discovery. Each chapter includes expert advice to not only provide a rigorous understanding of the principles being discussed, but to provide useful hints and tips gained from within the pharmaceutical industry. This expertise, combined with project case studies, highlighting and discussing all areas of successful projects, make this an essential handbook for all those involved in pharmaceutical development. A free iPad app has been created in collaboration with the editors of the book. The Medicinal Chemistry Toolkit provides a suite of resources to support the day to day work of a medicinal chemist. Search for "Medicinal Chemistry Toolkit."

Textbook Of Receptor Pharmacology Third Edition

Author: John C. Foreman
Publisher: CRC Press
ISBN: 1420052551
Size: 76.77 MB
Format: PDF
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Textbook Of Receptor Pharmacology Third Edition from the Author: John C. Foreman. For the past four decades, University College London has offered a renowned course on receptor pharmacology. Originating from this course, the perennially bestselling Textbook of Receptor Pharmacology has presented in-depth coverage of this rapidly expanding area of research. This third edition continues to combine current understanding of classical quantitative pharmacology and drug-receptor interactions with the basics of receptor structure and signal transduction mechanisms, providing an integrated analysis of the mechanisms of drug action at membrane receptors. The hallmark of this popular text is the uniting of four major approaches to the study of receptors: Molecular investigation of receptor structure Quantitative functional studies of agonists and antagonists Ligand binding Signal transduction at the cell membrane Maintaining the second edition’s focus on cell membrane receptors and the immediate signal transduction events at the membrane, this edition includes updated chapters on receptor structure and signal transduction by G-proteins and tyrosine kinases as well as enhancements to the quantitative treatment of drug-receptor interactions. Several chapters contain problems and worked-out solutions, giving students the ability to test their comprehension of the material. Hundreds of diagrams and figures further enhance the text. A time-saving resource and comprehensive learning tool, Textbook of Receptor Pharmacology, Third Edition carries on the tradition of providing in-depth, up-to-date coverage of this critical area that is both fundamental to the science of pharmacology and on the cutting edge of new drug development.

Handbook Of Methods For Designing Monitoring And Analyzing Dose Finding Trials

Author: John O'Quigley
Publisher: CRC Press
ISBN: 1351648020
Size: 12.94 MB
Format: PDF, Docs
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Handbook Of Methods For Designing Monitoring And Analyzing Dose Finding Trials from the Author: John O'Quigley. Handbook of Methods for Designing, Monitoring, and Analyzing Dose-Finding Trials gives a thorough presentation of state-of-the-art methods for early phase clinical trials. The methodology of clinical trials has advanced greatly over the last 20 years and, arguably, nowhere greater than that of early phase studies. The need to accelerate drug development in a rapidly evolving context of targeted therapies, immunotherapy, combination treatments and complex group structures has provided the stimulus to these advances. Typically, we deal with very small samples, sequential methods that need to be efficient, while, at the same time adhering to ethical principles due to the involvement of human subjects. Statistical inference is difficult since the standard techniques of maximum likelihood do not usually apply as a result of model misspecification and parameter estimates lying on the boundary of the parameter space. Bayesian methods play an important part in overcoming these difficulties, but nonetheless, require special consideration in this particular context. The purpose of this handbook is to provide an expanded summary of the field as it stands and also, through discussion, provide insights into the thinking of leaders in the field as to the potential developments of the years ahead. With this goal in mind we present: An introduction to the field for graduate students and novices A basis for more established researchers from which to build A collection of material for an advanced course in early phase clinical trials A comprehensive guide to available methodology for practicing statisticians on the design and analysis of dose-finding experiments An extensive guide for the multiple comparison and modeling (MCP-Mod) dose-finding approach, adaptive two-stage designs for dose finding, as well as dose–time–response models and multiple testing in the context of confirmatory dose-finding studies.? John O’Quigley is a professor of mathematics and research director at the French National Institute for Health and Medical Research based at the Faculty of Mathematics, University Pierre and Marie Curie in Paris, France. He is author of Proportional Hazards Regression and has published extensively in the field of dose finding. Alexia Iasonos is an associate attending biostatistician at the Memorial Sloan Kettering Cancer Center in New York. She has over one hundred publications in the leading statistical and clinical journals on the methodology and design of early phase clinical trials. Dr. Iasonos has wide experience in the actual implementation of model based early phase trials and has given courses in scientific meetings internationally. Björn Bornkamp is a statistical methodologist at Novartis in Basel, Switzerland, researching and implementing dose-finding designs in Phase II clinical trials. He is one of the co-developers of the MCP-Mod methodology for dose finding and main author of the DoseFinding R package. He has published numerous papers on dose finding, nonlinear models and Bayesian statistics, and in 2013 won the Royal Statistical Society award for statistical excellence in the pharmaceutical industry. ? ?

Receptor Biology

Author: Michael F. Roberts
Publisher: John Wiley & Sons
ISBN: 3527800158
Size: 13.11 MB
Format: PDF, ePub, Mobi
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Receptor Biology from the Author: Michael F. Roberts. This book is geared to every student in biology, pharmacy and medicine who needs to become familiar with receptor mediated signaling. The text starts with explaining some basics in membrane biochemistry, hormone biology and the concept of receptor based signaling as the main form of communication between cells and of cells with the environment. It goes on covering each receptor superfamily in detail including their structure and evolutionary context. The last part focusses exclusively on examples where thorough knowledge of receptors is critical: pharmaceutical research, developmental biology, neurobiology and evolutionary biology. Richly illustrated, the book is perfectly suited for all courses covering receptor based signaling, regardless whether they are part of the biology, medicine or pharmacology program.

Brody S Human Pharmacology

Author: Lynn Wecker
Publisher: Elsevier Health Sciences
ISBN: 0323075754
Size: 75.77 MB
Format: PDF, Mobi
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Brody S Human Pharmacology from the Author: Lynn Wecker. Featuring the contributions of leading faculty, this new edition provides a succinct overview of the most important aspects of pharmacology necessary for a basic understanding of the subject. It reviews the concepts, clinical applications and side effects of pharmacology, placing an emphasis on practical applications of the material, whenever possible. More than 480 full-color illustrations explain important processes, while color-coded boxes for major drugs, therapeutic overviews, clinical problems, and trade names—as well as USMLE-style self-assessment questions with answers and rationales—reinforce your mastery of the information. A consistent style of writing—and more focused, concise content—provide for better learning of the essentials. Online access to Student Consult—where you’ll find 15 pharmacology animations...150 USMLE-style questions...and more—further enhances your study and prepares you for exams. Includes online access to Student Consult where you’ll find USMLE-style questions, animations showing the actions of various important toxins, and much more. Focuses on the essential aspects of pharmacology for a solid foundation of knowledge in the subject. Includes more than 480 full-color illustrations that explain key pharmacologic processes. Provides between 4 and 6 USMLE-style self-assessment questions at the end of each chapter—with answers and full explanations in the appendix—that help you prepare for exams and master the material. Uses a templated format that promotes more effective and efficient learning. Presents color-coded boxes in each chapter that emphasize key points. Features a clinical emphasis throughout on both the basic science of pharmacology and its clinical relevance. Includes new Gold Standard content on Student Consult with 200 Professional Drug Monographs for additional information on generic and brand names, mechanism of action, pharmacokinetics, indications and dosage, drug interactions, patient education and much more! Features a more consistent style of writing—as well as focused, concise content—for enhanced learning of the essentials. Presents chapters in a re-arranged order for a more logical approach to learning. Includes additional biochemistry and physiology information in the introduction for each section for greater understanding.

Elements Of Pharmacology

Author: P. J. Bentley
Publisher: Cambridge University Press
ISBN: 9780521280747
Size: 30.95 MB
Format: PDF, ePub, Mobi
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Elements Of Pharmacology from the Author: P. J. Bentley. Written primarily for students of medicine, pharmacy, and pharmacology, this introductory book provides a concise summary of the principles that underlie the science of pharmacology. It presents the basic concepts required for understanding the use, mechanisms of action, toxicity and side effects, and therapeutic application of drugs in man. Thus the book may also be of interest to medical practitioners and to biological and medical scientists. Among topics covered are the sources of drugs, the way they are administered and dealt with in the body, as well as concepts about the nature of their actions. The last include their chemical interactions with components of cells and the manner in which these lead to therapeutically desirable as well as undesirable and even toxic effects. In addition, clinically related subjects, such as drug interactions, teratogenic and carcinogenic effects are discussed. The development and testing of new drugs are also described. For easy reference, at the back of the book there is a glossary of drugs named in the text.

Dental Hygiene

Author: Michele Leonardi Darby
Publisher: Elsevier Health Sciences
ISBN: 143770445X
Size: 70.25 MB
Format: PDF, Kindle
View: 1632
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Dental Hygiene from the Author: Michele Leonardi Darby. Comprehensive and up to date, Dental Hygiene, 3rd Edition offers complete coverage of today’s dental hygiene skills and theories -- all based on the Human Needs Model for better hygienist/patient communication. With a strong focus on clinical application, each section closely follows the critical thinking and clinical assessment approach that a hygienist must use in the classroom, clinic, and practice. Clinical competencies at the beginning of each chapter provide a clear, quick overview of exactly what you need to know, and procedure boxes with detailed steps and rationales ensure that you understand the reasoning behind each step in the competencies. In addition, new chapters on caries risk assessment and the oral-systemic health connection keep you up to date with today’s major areas of research. Each section takes you from conceptual foundations of dental hygiene through patient assessment, treatment, and evaluation. Scenario boxes challenge you to integrate complex information as you assess, diagnose, plan care, and evaluate the outcome of care. Client Education Issues and Legal, Ethical and Safety Issues boxes inform you of the latest information in these important areas. Critical Thinking exercises provide opportunities for independent thought and problem solving. Tables and boxes build upon and simplify information from the text, making study and review quick and easy. Evolve website contains free online resources, including weblinks, self-assessment quizzes, and professional development worksheets for student review. A reorganized section for Individuals with Special Needs includes chapters on Cleft Palate, Physical Abuse, Blood Diseases, and Mental Illness, all reflecting evidence-based research now available in these areas. New chapters on caries risk assessment and the oral-systemic health connection -- hot topics in today’s dental sciences. New anesthesia guidelines keep you up to date with what's new in pain and anxiety control. Essential resources and websites are now included at the end of each chapter for easy reference. New illustrations provide a fresh, reader-friendly design. Self-assessment quizzes are available online, all case-based to follow the NBDH format. Free online access to the Legal and Ethical Decision Making chapter, including an 'asset center' to assist you with clinical skills.

Cell Surface Receptors A Short Course On Theory And Methods

Author: Lee E. Limbird
Publisher: Springer Science & Business Media
ISBN: 9780792338390
Size: 55.83 MB
Format: PDF, Docs
View: 1889
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Cell Surface Receptors A Short Course On Theory And Methods from the Author: Lee E. Limbird. Cell Surface Receptors: A Short Course on Theory and Methods, Second Edition is a primer for the study of cell surface receptors. The simplified discussion of methods and their underlying principles removes the usual intimidation caused by the specialized vocabulary or sophisticated mathematics that characterize many of the primary papers in this field. In this way, the basic concepts become emphasized. This volume is a starting point: a textbook as well as a manual to which the investigator can return for a refresher course, when needed.